Pharmaceutical Raw Materials

Doxycycline Hyclate/ Doxycycline HCL

CAS:10592-13-9
Purity: 99%MIN
Appearance: Yellow powder
Package: 25kg drum
Product description: Its antibacterial spectrum is very close to Tetracycline and Terramycin, but it has better effect,
INQUIRY

Doxycycline Hyclate/Doxycycline HCL

Product Name: Doxycycline hydrochloride

CAS NO: 10592-13-9

Molecular formula: C22H24N2O8
Molecular weight: 444.4346

Flash point: 414.99°C

Standard: BP/EP/USP/JP

Purity: 99%MIN

Appearance: Light yellow or yellow crystalline powder

Solubility: Be freely soluble in water or methanol,slightly soluble in ethanol(96%) and acetone, almost insoluble in chloroform.

HS Code: 29413020.00

Application:

Its antibacterial spectrum is very close to Tetracycline and Terramycin, but it has better effect, be sensitive to the Staphylococcus Aureus of tetracycline-resistant, oxytetracycline, long lasting time.

Specification:

Item	Standard
Character	Yellow crystalline Powder
Solubility	Freely soluble in water and in methanol, sparingly soluble in ethanol ( 96 per cent ). It dissolves in solutions of alkali hydroxides and carbonates.
Identification	a) HPLC
	b) Sulphurie acid reaction a yellow colour develops
	c) It gives reaction of chlorides
PH	2.0-3.0
Specific Absorbance	At 349 nm E ( 1% ) 300-335 ( anhydrous and ethanol-free substance )
Specific Optical Rotation	-120°~-105° ( anhydrous and ethanol-free substance )
Heavy Metal	≤50ppm
Light-absorbing Impurities	At 490nm≤0.07 ( anhydrous and ethanol-free substance )
	a) 6-epidoxycycline ≤2.0%
	b) metacycline ≤2.0%
	c) 4-epidoxycycline ≤ 0.5%
	d) 4-epi-6-epidoxycycline≤ 0.5%
	e) oxytetracycline ≤ 0.5%
	f) 2-acety-2-decarbamoyldoxycycline ADOT ≤ 0.5%
	g) any other impurity≤ 0.5%
Ethanol	4.3-6.0% ( m/m )
Sulphated Ash	≤ 0.4%
Water	1.4-2.8%
Assay	95.0%-102.0% ( C22H25CIN2O8 ) ( anhydrous and ethanol-free substance )
Conclusion: This product fulfills EP7.4, BP2010.